E3: European Eye Epidemiology Consortium

About E3

The European Eye Epidemiology (E3) consortium is a cooperation between 31 groups originating from 13 different European countries. It comprises of both population-based and other studies (case-control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants.

OUR MISSION:

to promote and sustain collaboration and sharing of data and knowledge in the field of ophthalmic epidemiology in Europe, with particular focus on the harmonization of methods for future research, estimation and projection of frequency and impact of visual outcomes in European populations (including temporal trends and European subregions)

to identify risk factors and pathways for eye diseases (lifestyle, vascular and metabolic factors, genetics, epigenetics and biomarkers)

to develop and validate prediction models for eye diseases

"Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium."

MEMBERS

The European Eye Epidemiology (E3) consortium is a cooperation between 31 groups originating from 13 different European countries.

Population-based studies participating in E3

Study name	PI	Main publication
1958 British Birth cohort	Jugnoo Rahi
Alienor	Cécile Delcourt
Coimbra AMD - Mira Study	Rufino Silva
Coimbra DR Study	José Cunha-Vaz
EPIC-Norfolk	Paul Foster, Key-Tee Khaw
ERF	Caroline C.W. Klaver
Eureye	Astrid Fletcher
GA CIC XV XX	J.A Sahel
Generation R	Caroline C.W. Klaver
Gullstrand-Study (Leipzig data)	Franziska Rauscher
Gutenberg Health Study (GHS)	Norbert Pfeiffer	25775251
KORA	Konrad Oexle, Christian Gieger, Thomas Meitinger
LIFE Adult	Franziska Rauscher
LIFE Child	Franziska Rauscher
Maastricht Study	Tos Berendschot
Montrachet	Catherine Creuzot-Garcher
MRC Older People Study
Northern Ireland Cohort for the Longitudinal Study of Aging (NICOLA)	Ruth Hogg
PAMDI	Stefano Piermarocchi
POLA	Cécile Delcourt
Rotterdam Study I	Caroline C.W. Klaver	26386597
Rotterdam Study II	Caroline C.W. Klaver	26386597
Rotterdam Study III	Caroline C.W. Klaver	26386597
Thessaloniki Eye Study	Fotis Topouzis
Tromsø Eye Study	Geir Bertelsen
Twins UK	Chris Hammond
Young Finns Study	Terho Lehtimäki, Olli Raitakari

Other studies participating in E3

Study name	Country	PI	Main publication
AMRO-NL		Caroline C.W. Klaver
Belfast		Ruth Hogg, Usha Chakravarthy
Carotenoids in Age-Related Maculopathy (CARMA)		Usha Chakravarthy, Stephen Beatty
CIC XV XX		J.A Sahel
Creteil Study		Eric H Souied
Danish cohort of pediatric diabetes		Rebecca Broe
Early Observational Markers Study		Usha Chakravarthy, Giovanni Staurengi, Rufino Silva
EUGENDA		Carel B. Hoyng, Anneke I. den Hollander, S. Fauser
Fyns Diabetes Database		Jakob Grauslund
Guernsey AMD case cohort study		Andrew J Lotery
IVAN Study		Andrew J Lotery
Leiden University Medical Center Biobank		Camiel J.F. Boon
MARS		Hans-Werner Hense, Daniel Pauleikhoff
MYST		Caroline C.W. Klaver
Southampton AMD/glaucoma case–control Study		Andrew J Lotery
Southampton Liver Transplant		Andrew J Lotery
Southampton nystagmus		Jay Self
Southampton paediatric eye diseases		Jay Self
Southampton Pharmacogenetic Correlation in wet AMD		Andrew J Lotery
Southampton POAG		Andrew J Lotery
Southampton Rod-cone Dystrophies		Andrew J Lotery

PUBLICATIONS

	PubMed URL
Mauschitz MM, Bonnemaijer PWM, Diers K, Rauscher FG, Elze T, et al.; European Eye Epidemiology (E3) Consortium. Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population. Ophthalmology. 2018 Apr 28. [Epub ahead of print].	29716786
Delcourt C, Le Goff M, von Hanno T, Mirshahi A, Khawaja AP, et al. The Decreasing Prevalence of Nonrefractive Visual Impairment in Older Europeans: A Meta-analysis of Published and Unpublished Data. Ophthalmology. 2018 Mar 13. [Epub ahead of print].	29548645
Colijn JM, Buitendijk GHS, Prokofyeva E, Alves D, Cachulo ML, et al. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future. Ophthalmology. 2017 Dec;124(12):1753-1763.	28712657
Delcourt C, Korobelnik JF, Buitendijk GH, Foster PJ, Hammond CJ, et al. Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium. Eur J Epidemiol. 2016 Feb;31(2):197-210.	26686680
Khawaja AP, Springelkamp H, Creuzot-Garcher C, Delcourt C, Hofman A, et al. Associations with intraocular pressure across Europe: The European Eye Epidemiology (E3) Consortium. Eur J Epidemiol. 2016 Nov;31(11):1101-1111	27613171
Williams KM, Verhoeven VJ, Cumberland P, Bertelsen G, Wolfram C, et al. Prevalence of refractive error in Europe: the European Eye Epidemiology (E3) Consortium. Eur J Epidemiol. 2015 Apr;30(4):305-15.	25784363
Williams KM, Bertelsen G, Cumberland P, Wolfram C, Verhoeven VJ, et al. Increasing Prevalence of Myopia in Europe and the Impact of Education. Ophthalmology. 2015 Jul;122(7):1489-97.	25983215

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